The Potential of Stem Cells to Correct the Lost Tissue Mass in Liver and Kidney of Rat after Copper Toxicity
O. A. Abu-Zinadah and H. K. Hussein
Abstract: Background: The belief is that the genetic defects are responsible for disease and copper toxicosis is a cause rather than the result of tissue disease but it is not the primary cause. The tissue alterations, vacoulation, degeneration and necrosis, decreased after stopping copper toxicity and the organs excrete the excess copper by certain ways. The aim of this study was to show the potential of interstitial stem cells or their precursors to be involved in the regeneration of the lost tissue mass in liver and kidneys after copper toxicity clearance. Result: The present experiment was designed using the local albino Sprague Dawely rats. The animals were sacrificed during and after toxication period as well as after non-toxication periods. Copper accumulates in animal tissues until reaching the toxic level, at which time the histopathological changes then develops. Conclusion: This clearance enhances the interstitial stem cells or their precursors to incorporate in regeneration of the lost tissue mass. Moreover, to some extents, the bone marrow stem cells may introduce some plasticity to regenerate some of this lost tissue mass. The results support the opinion that the interstitial stem cells or even bone marrow stem cells are incorporated into regeneration of the lost tissues after toxication and clearance.
Fulltext   HTML  /  PDF    |
		How to Cite: O. A. Abu-Zinadah and H. K. Hussein , 2011. The Potential of Stem Cells to Correct the Lost Tissue Mass in Liver and Kidney of Rat after Copper Toxicity. Insight Stem Cell Research, 1: 1-5 DOI: 10.5567/ISCR-IK.2011.1.5
Related Articles
Clastogenic effects of copper sulphate in chick in vivo test system
Effects of tempol and redox-cycling nitroxides in models of oxidative stress
Comparison of cytotoxicity of cysteine and homocysteine for renal epithelial cells
Zinc, copper and iron metabolism during porcine fetal development