The manuscript has withdrawn due to plagiarism
Both insulin resistance and type 2 diabetes are associated with obesity which
is known as a major risk factor for pathogenesis of these diseases and act mainly
through the secretion of adipokines such as TNF-α that may influence
insulin sensitivity. TNF-α affects many aspects of adipocyte function,
such as adipocyte development and lipid metabolism. There is a correlation between
the expressions of TNF-α in retroperitoneal WAT and insulin-resistance
in 8 genetically obese fa/fa rats. Treatment of animals with CL316, 243, a α3-adrenergic
agonist, showed an improvement of insulin-resistance that was associated with
the suppression of TNF-α mRNA expression in WAT. These results confirm
the association between TNF-α expression and the insulin-resistant condition
in rats. Our finding indicates that the hyperglycaemia and hyperinsulinemia
induced by insulin-resistance correlated positively with the expression of TNF-α
mRNA in an abdominal WAT depot. We conclude that CL316, 243 possesses both anti-diabetic
effects and anti-obesity effects in rodents.
