Modulation of Virulence Factors of Staphylococcus aureus by Nasal Decongestants
Jefferson Celli Honorio , Cristina Rauen Ribas , Maria Fernanda Cordeiro Arruda , Luiz Fernado Bianchini , Patricia Maria Stuelp Campelo and Edvaldo Aatonio Ribeiro Rosa
Abstract: Background and Objective: When applied, nasal decongestants may reach cells of Staphylococcus aureus, a bacterium that commonly colonizes the mucosa. The aim of this study was to evaluate experimentally the effect of corticoids (budesonide, dexamethasone and triamcinolone), alpha-agonists (naphazoline, oxymetazoline, fenoxazoline and xylometazoline) on biofilm formation and secretion of staphylococcal haemolysin and proteases. Materials and Methods: Commercial formulations had their preservatives neutralized and were added to the culture broth in which the strain ATCC®25923™ was grown. The biofilm production was measured after 72 h of incubation. This study investigated the proteolytic and haemolytic activities of culture supernatant for the interval between the 48-72 h of incubation. Results: It was obtained that there are interactions amongst decongestants and S. aureus as biomass reductions (budesonide, triamcinolone and fenoxazoline), protease activity (triamcinolone), specific protease activity (triamcinolone), haemolytic index (budesonide, triamcinolone and dexamethasone) and specific haemolytic index (budesonide, triamcinolone and dexamethasone). On the other hand, xylometazoline increased the rate of haemolysin secretion. Conclusion: These interactions may albeit not in a unanimous manner and be beneficial to decongestants users.
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		How to Cite: Jefferson Celli Honorio, Cristina Rauen Ribas, Maria Fernanda Cordeiro Arruda, Luiz Fernado Bianchini, Patricia Maria Stuelp Campelo and Edvaldo Aatonio Ribeiro Rosa , 2016. Modulation of Virulence Factors of Staphylococcus aureus by Nasal Decongestants. Insight Microbiology, 6: 1-6 DOI: 10.5567/IMICRO-IK.2016.1.6