IgE and Cytokines (IL-6 and IL-13) in Sinonasal Polyposis
S.M. Elmorsy , Y.W. Khafagy , N.M. Rizk , M.M. El-Naggar , S. Taher , W.K. Mowafy and M.S. Rizk
Abstract: Background: This study aimed to evaluate local IgE together with cytokines IL-6 and IL-13 in nasal polyposis. Twenty eight patients with sinonasal plyposis were classified into allergic group and non allergic group. Serum and polyp fluid IgE, IL-6 and IL-13 were measured by ELISA. The amount of serum and polyp tissue albumin was determined. Result: The mean value of IgE in polyp fluid in allergic group is statistically significantly higher compared to that in non allergic group. Regarding cytokines assay, the mean values of both IL-6 and IL-13 in polyp fluid of allergic group are statistically significantly higher than that in non allergic group. In allergic group, the mean value in serum IgE expressed as percentage to serum albumin is statistically significantly higher than that of non allergic group. There is no significant difference regarding IL-6 concentration in sera of both groups. There is a statistically significant increase in the amount of IL-13 in sera of allergic group compared to control group. Conclusion: There is increased expression of IgE, IL-6 and IL-13 in nasal polyps extracted from patients with allergic rhinitis. There is a statistically significant increase in the amount of IgE and IL-13 in sera of allergic group compared to control group.
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		How to Cite: S.M. Elmorsy, Y.W. Khafagy, N.M. Rizk, M.M. El-Naggar, S. Taher, W.K. Mowafy and M.S. Rizk , 2011. IgE and Cytokines (IL-6 and IL-13) in Sinonasal Polyposis. Insight Immunology, 1: 1-5 DOI: 10.5567/IMMUN-IK.2011.1.5
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