Volume 8 No. 1, 2018
 
 
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Insight Pharmaceutical Sciences>>  Volume 8 Issue 1, 2018
Determination of Fluconazole in Bulk Durg and its Solid Formulations by Acid-base Titration in Non-aqueous Medium
Vamsi Krishna Penmatsa and Basavaiah Kanakapura
 
Abstract: Background: Fluconazole (FLK) is a synthetic triazole derivative antifungal agent that has been shown to be effective against a wide range of systemic and superficial fungal infections. Objective: Two simple, rapid, reliable, precise and accurate and cost-effective non-aqueous titrimetric procedures have been developed for the determination of FLK in bulk drug and its pharmaceutical formulations. Materials and Methods: The methods are based on the titration of the drug with perchloric acid in glacial acetic acid with the visual end point detection using crystal violet as indicator or the potentiometric end point using a combined double junction pH electrode system. Results: The methods were applicable over the range of 2.0-15.0 mg FLK and the calculations are based on a 1:2 reaction stoichiometry. The procedures were also applied for the determination of FLK in its dosage forms and the results were found to be in a good agreement with those obtained by the reference method. The precision results expressed by intra-day and inter-day relative standard deviation values were good (RSD<0.75%). The accuracy was satisfactory as well (RE≤1.30%). Excipients used as additives in pharmaceutical formulations did not interfere in the proposed procedures as shown by the recovery study via standard addition technique recoveries in the range 99.23-101.03% with a standard deviation of ≤0.91%. Conclusion: The proposed methods were applied for determination of the FLK in tablets. Both the methods were validated and can be suggested for routine analysis in quality control department.
 
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    How to Cite:
Vamsi Krishna Penmatsa and Basavaiah Kanakapura , 2018. Determination of Fluconazole in Bulk Durg and its Solid Formulations by Acid-base Titration in Non-aqueous Medium. Insight Pharmaceutical Sciences, 8: 13-20
DOI: 10.5567/IPHARMA-IK.2018.13.20
 
 
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