Volume 8 No. 1, 2018
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Issue 1
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Insight Pharmaceutical Sciences>>  Volume 8 Issue 1, 2018
Anti-microbial and Anti-oxidant Properties of Cunninghamia lanceolata
Poonam Jyoti , Khem Raj Meena , Abhishek Sharma , Rita Kapoor , Tanvi Sharma and Shamsher Singh Kanwar
Abstract: Objective: In the present study, an attempt was made to evaluate antimicrobial and antioxidant potential of alcoholic plant extract (APE) of a selected plant Cunninghamia lanceolata (C. lanceolata) to understand the phytochemical properties of the APE. The APE was also screened for the presence of flavonoids, proteins and phenolic compounds, which are the major constituents responsible for efficient antimicrobial and antioxidant activities. Materials and Methods: Plant tissue extract was prepared from the selected plant Cunninghamia lanceolata. Various phytochemicals studies were performed to check the flavonoids, phenolics and protein contents by the spectrophotometry method. Antioxidant properties were analyzed by the DPPH as well as by H2O2 assay. Further antimicrobial activities against the selected bacterial and fungal pathogens were also checked by the spread plate methods. Standard deviation (SD) about the mean was calculated from data obtained for 3 replicates for each of the parameters studied. Results: Qualitative analysis of crude APE of C. lanceolata showed proteins (17.7 mg mL–1), flavonoids (2.35 mg mL–1) and phenols (0.19 mg mL–1). The crude APE of C. lanceolata was revealed that maximum zone of clearance was observed against Klebsiella pneumoniae (23.6 mm) with (minimum inhibitory concentration) MIC value was 0.36 mg mL–1 out of the selected bacterial strains while maximum antifungal activity (zone of clearance) was observed against Aspergillus niger (18.5 mm). DPPH and H2O2 retain the scavenging activity with 85.1 and 51.7%, respectively. While ferrous ion chelating activity of APE of the C. lanceolata was observed with 81.5%. Conclusion: The APE of C. lanceolata was found a potential source of natural antioxidant as well as strong antimicrobial agent which have high content of protein, flavonoids and phenolics.
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Poonam Jyoti, Khem Raj Meena, Abhishek Sharma, Rita Kapoor, Tanvi Sharma and Shamsher Singh Kanwar , 2018. Anti-microbial and Anti-oxidant Properties of Cunninghamia lanceolata. Insight Pharmaceutical Sciences, 8: 21-27
DOI: 10.5567/IPHARMA-IK.2018.21.27
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